Tox and Hound – Fellow FridayWhat Terror Hath NAPQI Wrought? From NAPQI to Hepatic Necrosis to Fomepizole Steven Curry, M.D.University of Arizona College of Medicine – PhoenixDepartment of Medical ToxicologyBanner – University Medical Center PhoenixPhoenix, AZ Introduction Medical toxicology fellows can recite the routes of acetaminophen (APAP) metabolism in their sleep. And they know that […]
Tox and Hound – Unconscious Uncoupling – Managing pH in Salicylate Overdoses
by Dan Rusyniak When Gwyneth Paltrow “consciously uncoupled” from Chris Martin, I immediately thought of mitochondria. Why mitochondria? For one because mitochondria are the favorite organelle of toxicologists (sorry, sarcoplasmic reticulum . . .). And second, because I am fascinated by drugs that uncouple oxidative phosphorylation. There are lots of toxins that target mitochondria. There […]