by Howard Greller Recently, I’ve moved offices, and came across a number of old letters. A lot of it was just regular business stuff (e.g., credentialing packets, requests for privileges, a metric ton of menus, etc.), but there was a significant amount of correspondence as well, including some letters of a personal nature. In lieu […]
Tox and Hound – Unconscious Uncoupling – Managing pH in Salicylate Overdoses
by Dan Rusyniak When Gwyneth Paltrow “consciously uncoupled” from Chris Martin, I immediately thought of mitochondria. Why mitochondria? For one because mitochondria are the favorite organelle of toxicologists (sorry, sarcoplasmic reticulum . . .). And second, because I am fascinated by drugs that uncouple oxidative phosphorylation. There are lots of toxins that target mitochondria. There […]
Tox and Hound – The Sound of Silence
By Diane Calello In 2001, radio talk show host Rush Limbaugh announced to his listeners that he woke up one morning deaf in his right ear and that deafness had progressed to complete hearing loss over 4 months. A tentative diagnosis of autoimmune hearing loss was made, and he received cochlear implants, restoring his hearing. […]
Tox and Hound – To Bind or Not To Bind
by Jeanna Marraffa If you’re the gambling type, then this post is for you! 50/50 are pretty good odds, right? Or are they not and that’s why I never win in Vegas? I digress . . . let’s get back to the poll. Fifty percent of people said that they wouldn’t give digoxin-Fab to a […]
Tox and Hound – Talking Back to a Talking Antidote
By Andrew Stolbach Author’s note: I sat down to discuss the role of the out-of-hospital naloxone administration with Evzio® (Kaleo Pharmaceuticals), the world’s only talking naloxone auto-injector. Our interview is presented below in its entirety. AS: Thanks for coming today. Evzio®: To Inject. Place black end against outer thigh. Then press firmly. 5, 4, 3, […]
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