by Diane Calello Risk Assessment in Acetaminophen Toxicity In the beginning God created the heavens and the earth. Darkness covered the formless earth, wind swept over the waters. And God said, “Let there be acetaminophen”. And so it was. And it was good. Then man discovered acetaminophen and, realizing he was naked without it, covered […]
Tox and Hound – Sneaking into the Party
by Sarah Shafer How does a heart break? In the case of beta-blocker (BB) and calcium-channel blocker (CCB) overdose, it’s a lack of calcium. Calcium is essential to muscle contraction, allowing actin and myosin to interact so that the cell shortens. Without calcium, the myosin and actin are blocked from interacting, and the cell stays […]
Tox and Hound – Check Yourself
by Andrew Stolbach The history of cancer therapy is entwined with the history of the 20th and 21st centuries. Scientific discovery does not occur in a historical vacuum. The swirl of world events does not stop outside the laboratory. In 1910, as Viennese researchers Ernest Freund and Gisa Kaminer published observations that some substance in […]
Tox and Hound – U(ds) and I
by Howard Greller Recently, I’ve moved offices, and came across a number of old letters. A lot of it was just regular business stuff (e.g., credentialing packets, requests for privileges, a metric ton of menus, etc.), but there was a significant amount of correspondence as well, including some letters of a personal nature. In lieu […]
Tox and Hound – Unconscious Uncoupling – Managing pH in Salicylate Overdoses
by Dan Rusyniak When Gwyneth Paltrow “consciously uncoupled” from Chris Martin, I immediately thought of mitochondria. Why mitochondria? For one because mitochondria are the favorite organelle of toxicologists (sorry, sarcoplasmic reticulum . . .). And second, because I am fascinated by drugs that uncouple oxidative phosphorylation. There are lots of toxins that target mitochondria. There […]
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