by Dan Rusyniak Vilazodone an SSRI with partial agony properties. When we think about the one-pill-can-kill drugs in kids, selective serotonin reuptake inhibitors (SSRIs) are notably absent. Although they can cause serotonin syndrome, toxicity from these drugs usually require ingestions of multiple agents or a single large ingestion. There are of course exceptions to every rule. […]
Tox and Hound – The Dirty on Dantrolene
by Sarah Shafer Dantrolene is one of the few, true “muscle relaxers”. It was discovered in 1967 and approved by the FDA in 1979. Unlike paralytic neuromuscular blockers, dantrolene works post-synaptically, at the sarcoplasmic reticulum in the myocyte. It binds to the ryanodine receptor in skeletal muscle (RYR1), preventing sarcoplasmic calcium-induced calcium release. When RYR1 […]