Tox and Hound – Fellow FridayWhat Terror Hath NAPQI Wrought? From NAPQI to Hepatic Necrosis to Fomepizole Steven Curry, M.D.University of Arizona College of Medicine – PhoenixDepartment of Medical ToxicologyBanner – University Medical Center PhoenixPhoenix, AZ Introduction Medical toxicology fellows can recite the routes of acetaminophen (APAP) metabolism in their sleep. And they know that […]
Tox and Hound – In the Beginning
by Diane Calello Risk Assessment in Acetaminophen Toxicity In the beginning God created the heavens and the earth. Darkness covered the formless earth, wind swept over the waters. And God said, “Let there be acetaminophen”. And so it was. And it was good. Then man discovered acetaminophen and, realizing he was naked without it, covered […]