Cellular Efflux of Protons and Lactate Steven C Curry, MDUniversity of Arizona College of Medicine – PhoenixBanner – University Medical Center PhoenixPhoenix, AZ@SteveCurryMD Robert A Robergs, Ph.D.School of Exercise and Nutrition Sciences, Faculty of HealthQueensland University of TechnologyBrisbane, QLD, Australia As noted in the comments in the post on the origins of protons in lactic […]
Tox and Hound – Fellow Friday – Whence the Protons of Lactic Acidosis?
Whence the Protons of Lactic Acidosis? The case of impaired mitochondrial electron transport Steven C Curry, MDUniversity of Arizona College of Medicine – PhoenixBanner – University Medical Center PhoenixPhoenix, AZ@SteveCurryMD Robert A Robergs, Ph.D.School of Exercise and Nutrition Sciences, Faculty of HealthQueensland University of TechnologyBrisbane, QLD, Australia **NEW** – When finished with this first part, […]
Tox & Hound – MALA-ficence
Predicting Outcome in Metformin Lactic Acidosis by Diane Calello A 56-year-old male with diabetes and hepatitis comes in after an intentional overdose of his own metformin. On evaluation, he is awake and alert but mildly tachycardic. Lab evaluation demonstrates elevated lactate at 4 mmol/L and a pH of 7.3. Will he die? Metformin is one […]
Tox and Hound – Don’t Wernicke’s, B(1) Happy
by Meghan Spyres You take the perilous sign out of a 55-year-old patient with alcohol use disorder (AUD) who came to the ED intoxicated. “He’s just metabolizing” your colleague tells you. A few hours go by and he is now awake and asking to leave. The nurse road tests him and he can walk, but […]