by Dan Rusyniak Stimulant-Induced Hyperthermia, a (sort of) memoir. I will admit my biases up front. This post is based primarily on my own research or the research of people I have collaborated with. There may be other viewpoints out there, but I will stick with what and who I know. If someone disagrees with […]
The Dantastic Mr. Tox & Howard – S02E06 – The Ergogenic Academic
Dantastic Live at NACCT 2018 . . . &Howard That’s not a lump of coal in your stocking . . . Join Dan (@drusyniak) &Howard (@heshiegreshie) as they speak with Dr. Dan Rusyniak (@drusyniak) live on stage at the 2018 North American Congress of Clinical Toxicology Pre-Meeting Symposium. Dan cleverly tricked Howard into being the foil […]
Tox and Hound – The Dirty on Dantrolene
by Sarah Shafer Dantrolene is one of the few, true “muscle relaxers”. It was discovered in 1967 and approved by the FDA in 1979. Unlike paralytic neuromuscular blockers, dantrolene works post-synaptically, at the sarcoplasmic reticulum in the myocyte. It binds to the ryanodine receptor in skeletal muscle (RYR1), preventing sarcoplasmic calcium-induced calcium release. When RYR1 […]