by Jon Cole and Meghan Spyres Jon: Meghan, thank you for joining me on this post. I’ve wanted to write about the logistics of high dose insulin (HDI) for some time now, but I have a lot of my own biases about where insulin belongs in the ordering of our therapies for sick cardiotoxic overdoses […]
Tox & Hound – A Toxicological Brain Teaser. The Complexities of Valproic Acid Metabolism.
by Christine Murphy What do you think about when you hear the words “drug toxicity”? Do you think about a patient who overdosed or someone who is experiencing a toxic side effect from a medication? A lot of times, the answer might depend on what we remember about a drug when we hear the name. […]
“B-Sides” in Analgesia
by Meghan Spyres Ketamine was gifted to the world as a result of investigations into its evil older brother: phencyclidine (PCP). PCP, commonly known as ‘angel dust’ (quite the misnomer, Urban Dictionary suggests the use of the more fitting ‘devil dust’. . .) was initially used as a pharmaceutical in the 1950s under trade name […]
Tox & Hound – MALA-ficence
Predicting Outcome in Metformin Lactic Acidosis by Diane Calello A 56-year-old male with diabetes and hepatitis comes in after an intentional overdose of his own metformin. On evaluation, he is awake and alert but mildly tachycardic. Lab evaluation demonstrates elevated lactate at 4 mmol/L and a pH of 7.3. Will he die? Metformin is one […]
Tox and Hound – Happy New Year!
We here at the hive mind of the Tox and the Hound just want to thank you, dear readers, for joining us on this incredible journey. We’ve had an exciting year, where we’ve talked about a wide range of topics and ideas. We discussed . . . Post mortem drug redistribution Buprenorphine in the ER […]
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