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The Tox and the Hound

Toxicologists Writing About Toxicology

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Tox and Hound – Fellow Friday – Whence the Protons of Lactic Acidosis, Part II

August 14, 2020 by Tox & Hound 3 Comments

Cellular Efflux of Protons and Lactate Steven C Curry, MDUniversity of Arizona College of Medicine – PhoenixBanner – University Medical Center PhoenixPhoenix, AZ@SteveCurryMD Robert A Robergs, Ph.D.School of Exercise and Nutrition Sciences, Faculty of HealthQueensland University of TechnologyBrisbane, QLD, Australia As noted in the comments in the post on the origins of protons in lactic […]

Tox and Hound – Fellow Friday – Whence the Protons of Lactic Acidosis?

July 24, 2020 by Tox & Hound 19 Comments

Whence the Protons of Lactic Acidosis? The case of impaired mitochondrial electron transport Steven C Curry, MDUniversity of Arizona College of Medicine – PhoenixBanner – University Medical Center PhoenixPhoenix, AZ@SteveCurryMD Robert A Robergs, Ph.D.School of Exercise and Nutrition Sciences, Faculty of HealthQueensland University of TechnologyBrisbane, QLD, Australia **NEW** – When finished with this first part, […]

The Dantastic Mr. Tox & Howard – S03E03 – Inside Out

July 6, 2020 by Tox & Hound 2 Comments

Ingestible electronic systems, Mario and Luigi’s new digs, and human energy harvesting with Dr. Peter Chai. We’re back! Join Dan (@drusyniak) &Howard (@heshiegreshie) as they explore the GI tract of the city, build a career of excrement, and determine which bathroom is the cleanest with Dr. Peter Chai (@PeterRchai). We hope that everyone stays safe, […]

Tox and Hound – Love and Half-Life*

February 26, 2020 by Tox & Hound 1 Comment

by Sarah Shafer *Not the video game I’ve gotten some version of this call many times in my budding career as a medical toxicologist: “Hello, we have a something-year-old patient in the ER who overdosed on ______ (fill in the blank) medication. How long do we need to watch them before we can medically clear […]

Tox and Hound – One Therapy To Rule Them All? Sugar vs Squeeze in Cardiotoxic Poisoning

February 18, 2020 by Tox & Hound 2 Comments

by Jon Cole and Meghan Spyres Jon: Meghan, thank you for joining me on this post. I’ve wanted to write about the logistics of high dose insulin (HDI) for some time now, but I have a lot of my own biases about where insulin belongs in the ordering of our therapies for sick cardiotoxic overdoses […]

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